Monday, November 24, 2008

Drinkin' Wine, Spodee-O-Dee! :)

From a very good friend: Shayna. Read and "Drink up, Dudes and Dudettes". :)

I even have you some good wine-drinkin' music to go along with the reading material below........

Shayna, this one's for you, Hon!

How Red Wine Compounds Fight Alzheimer's Disease (


ScienceDaily (Nov. 23, 2008) — Scientists call it the "French paradox" — a society that, despite consuming food high in cholesterol and saturated fats, has long had low death rates from heart disease. Research has suggested it is the red wine consumed with all that fatty food that may be beneficial — and not only for cardiovascular health but in warding off certain tumors and even Alzheimer's disease.

Now, Alzheimer's researchers at UCLA, in collaboration with Mt. Sinai School of Medicine in New York, have discovered how red wine may reduce the incidence of the disease. Reporting in the Nov. 21 issue of the Journal of Biological Chemistry, David Teplow, a UCLA professor of neurology, and colleagues show how naturally occurring compounds in red wine called polyphenols block the formation of proteins that build the toxic plaques thought to destroy brain cells, and further, how they reduce the toxicity of existing plaques, thus reducing cognitive deterioration.

. . .

Teplow's lab has been studying how amyloid beta (Aß) is involved in causing Alzheimer's. In this work, researchers monitored how Aß40 and Aß42 proteins folded up and stuck to each other to produce aggregates that killed nerve cells in mice. They then treated the proteins with a polyphenol compound extracted from grape seeds. They discovered that polyphenols carried a one-two punch: They blocked the formation of the toxic aggregates of Aß and also decreased toxicity when they were combined with Aß before it was added to brain cells.

"What we found is pretty straightforward," Teplow said. "If the Aß proteins can't assemble, toxic aggregates can't form, and thus there is no toxicity. Our work in the laboratory, and Mt. Sinai's Dr. Giulio Pasinetti's work in mice, suggest that administration of the compound to Alzheimer's patients might block the development of these toxic aggregates, prevent disease development and also ameliorate existing disease."

Human clinical trials are next.

"No disease-modifying treatments of Alzheimer's now exist, and initial clinical trials of a number of different candidate drugs have been disappointing," Teplow said. "So we believe that this is an important next step."


First in line for the human clinical trials! WHOO-HOO! :)

Y'all have a great week, and don't forget to send an e-mail to Oprah and ask her to do a show on Alzheimer's. Be sure to click on the e-mail section!




Anonymous said...

Bill, you are so funny! LOVE that song to go with the article! And thank you for dedicating it to me. You're such a doll and I hope and pray that the research that's ongoing will be the breakthrough you need! In the meantime, at least you can be drunk through it. ;)

Jill (aka Shayna)

Bill Craig said...


When you look at this shit through laughing eyes, it ain't so bad, and as long as I have friends like you, I'll do my best to keep my perspective.